Scleroderma is a complex autoimmune disease accompanied by abnormal growth of connective tissue that causes thickening and hardening of the skin and other tissues. Testing for specific antibodies, such as anti-Scl-70, CENP B, and others, is an important part of the diagnostic process for scleroderma. These antibodies can provide information about the type and severity of the disease, which is essential for making a correct diagnosis and determining an appropriate treatment plan to improve patient outcomes.